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Cat. No.	Product Name	Target	Signaling Pathways
T3458	EED226	Histone Methyltransferase	Chromatin/Epigenetic
	EED226 是多梳抑制复合物 2 抑制剂，是一种有效的、选择性的、可口服的胚胎外胚层发育 (EED) 抑制剂，IC50 为 22 nM，具有强抗肿瘤活性。当 H3K27me0 肽用作体外酶法测定的底物时，它抑制 PRC2的 IC50为 23.4 nM。
T17649	Boc-GABA-OH	Others; PROTAC Linker	Others; PROTAC
	Boc-GABA-OH 是一种 PROTAC linker，可用于 UNC6852 的合成。其中 UNC6852 是靶向 EED 的 PROTAC 降解剂。
T13954	UNC6852	Histone Methyltransferase; Ligands for Target Protein for PROTAC	Chromatin/Epigenetic; PROTAC
	UNC6852 包含一个 EED 配体 (IC50 = 247 nM) 和一个 von Hippel-Lindau 配体，是一种基于 PROTAC 的特异性多梳抑制复合物 2 (PRC2) 降解剂。
T9681	MAK-683 hydrochloride	Histone Methyltransferase	Chromatin/Epigenetic
	MAK683 hydrochloride 是胚胎外胚层发育 (EED) 抑制剂。MAK683 hydrochloride 在 EED Alphascreen， ELISA 和 LC-MS 试验中测得的IC50 值分别为 59，26，89 nM。
T22322	EEDi-5285 UM-EEDi-5285,EEDI5285	Histone Methyltransferase	Chromatin/Epigenetic
	EEDi-5285 是一种非常有效且具有口服活性的胚胎外胚层发育 (EED) 抑制剂，结合 EED 蛋白的 IC50 值为 0.2 nM，并具有抗癌活性。
T15201	MAK683	Histone Methyltransferase	Chromatin/Epigenetic
	MAK683 是胚胎外胚层发育 (EED) 抑制剂。在 EED Alphascreen 结合、LC-MS 和 ELISA 测定中，IC50值为 59、89 和 26 nM。
T61825	EED ligand 1
	EED ligand 1 is a highly versatile, potent, and effective inhibitor that specifically targets the EED subunit of the polycomb repressive complex 2 (PRC2) methyltransferase.
T12554	PROTAC EED degrader-2	Others	Others
	PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.
T12553	PROTAC EED degrader-1	Others	Others
	PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.
T40223	EEDi-5273
	EEDi-5273 is a highly potent and orally efficacious inhibitor of EED, with an approximate IC50 value of 0.2 nM. This compound exhibits exceptional activity, capable of achieving complete and persistent regression of tumors.
T40154	FTX-6058
	FTX-6058 is a potent orally active inhibitor targeting Embryonic Ectoderm Development (EED). It effectively induces HbF protein expression in both cell and murine models. This compound holds significant potential for researching select hemoglobinopathies such as sickle cell disease and β-thalassemia.
T61975	Pociredir
	Pociredir (FTX-6058) 是一种有效的、选择性的、具有口服活性的胚胎外胚层发育蛋白 (EED) 小分子抑制剂（KD= 0.163 nM）。Pociredir (FTX-6058) 在研究炎症或血红蛋白病中具有研究价值，如镰状细胞病 (SCD)。
T40155	FTX-6058 hydrochloride
	FTX-6058 hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED), with the ability to induce HbF protein expression in both cell and murine models. This compound is particularly valuable in the research of select hemoglobinopathies, such as sickle cell disease and β-thalassemia.

化合物

Cat.No: T3458

Target: Histone Methyltransferase

Cat.No: T17649

Target: Others, PROTAC Linker

Cat.No: T13954

Target: Histone Methyltransferase, Ligands for Target Protein for PROTAC

MAK-683 hydrochloride

Cat.No: T9681

Target: Histone Methyltransferase

Cat.No: T22322

Synonym: UM-EEDi-5285,EEDI5285

Target: Histone Methyltransferase

Cat.No: T15201

Target: Histone Methyltransferase

Cat.No: T61825

PROTAC EED degrader-2

Cat.No: T12554

Target: Others

PROTAC EED degrader-1

Cat.No: T12553

Target: Others

Cat.No: T40223

Cat.No: T40154

Cat.No: T61975

FTX-6058 hydrochloride

Cat.No: T40155

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